Debut weekends for the last three "X-Men" movies ranged from $85.1 million to $102.8 million. The original "X-Men" opened 11 years ago with $54.5 million, but that would amount to about $80 million today adjusting for ticket-price inflation.
The movie added $64 million from 74 overseas markets for a worldwide total of $120 million.
"The Hangover Part II," fell to second-place with $32.4 million and "Kung Fu Panda 2" slipped to third place with $24.3 million.
Rounding off the top five movies of the weekend were "Pirates of the Caribbean: On Stranger Tides," with $18 million and "Bridesmaids" with $12.1 million.
The top 10 movies of the weekend were:
1. "X-Men: First Class," $56 million.
2. "The Hangover Part II," $32.4 million.
3. "Kung Fu Panda 2," $24.3 million.
4. "Pirates of the Caribbean: On Stranger Tides," $18 million.
5. "Bridesmaids," $12.1 million.
6. "Thor," $4.2 million.
7. "Fast Five," $3.2 million.
8. "Midnight in Paris," $2.9 million.
9. "Jumping the Broom," $865,000.
10. "Something Borrowed," $835,000.
The Associated Press contributed to this report.