The country star announced Wednesday she'll join fellow Canadian Celine Dion and take up residency at The Colosseum at Caesars Palace.
It's been seven years since Twain last toured.
Her new show will be called "Shania: Still the One" and will feature her biggest hits, including "You're Still The One" and "Forever And For Always". She'll play 60 shows a year beginning December 1, 2012.
Twain is the best-selling female country artist of all time. She has sold more than 75 million albums worldwide.
To get more information about Twain's new show and purchase tickets, go to www.shaniainvegas.com.