David Duchovny and Tea Leoni have separated, a spokesperson for Duchovny confirmed to OnTheRedCarpet.com on Tuesday.
The couple has been married since 1997. They have two children, daughter Madelaine, 12, and son Kyd, 9. The spokesperson had no further comment on the matter.
Duchovny, 50, and Leoni, 45, separated briefly in 2008 shortly after the actor checked himself into rehab for sex addiction. Duchovny completed treatment in October 2008 and the couple reconciled in 2009.
Duchovny is best known for his roles on "Californication," which is gearing up for a fifth season on Showtime this year, and "The X-Files." Leoni will next appear in "Tower Heist" opposite Ben Stiller, Eddie Murphy, Mathew Broderick and Casey Affleck. The film is set for release on November 4, 2011.