The show will be taped in Los Angeles and air on Sept. 19, the same night Ashton Kutcher debuts as Sheen's replacement in the CBS comedy, "Two and a Half Men."
Sheen was thrown off the show after his partying and bizarre behavior forced a production shutdown.
The Comedy Central roast is scheduled for 10 p.m., an hour after "Two and a Half Men."
"You could say I've been providing kindling for this roast for a while. It's time to light it up. It's going to be epic," said Sheen.
The Associated Press contributed to this report.