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OTRC: Chelsea Handler's sitcom loses 3 actors before debut, report says

Chelsea Handler appears in a promotional photo for 'Chelsea Lately.' / A scene from the pilot of NBC's 'Are You There, Vodka? It's Me, Chelsea.' Pictured: Lauren Lapkus as Dee Dee, Natalie Morales as Ivory, Laura Prepon as Chelsea. (E! Entertainment Television / Adam Rose / NBC)

Chelsea Handler's new NBC comedy series, "Are You There, Vodka? It's Me, Chelsea," has reportedly already lost three actors ahead of its midseason debut.

The show is based on Handler's memoir by the same name and stars Laura Prepon from the sitcom "That '70s Show" as the talk show host and comedienne. Handler plays her own sister, Sloane. The show depicts the title star's life in Los Angeles.

Joy Koy, who has appeared on Handler's E! Entertainment talk show "Chelsea Lately," Angel Laketa Moore of "ER" fame and Natalie Morales from NBC series "Parks and Recreation" were cast on "You There, Vodka? It's Me, Chelsea" but were recently "let go" for "creative reasons," TV Line reported. An NBC spokesperson had no immediate comment. The three appear in promotional photos for the NBC pilot.

"Chelsea is young, strong-willed, and a force of nature determined to live life to the fullest and make no apologies," reads NBC's official description for the show. "Her friends are along for the ride, but they all know it's Chelsea's way or the highway."

Koy was to play "a charming bartender whose wit makes him the perfect foil for Chelsea." Moore was originally cast as "a smart and sassy fellow waitress who looks out for Chelsea's best interests" and Morales' character, Ivory, was described as "Chelsea's feisty best friend."

Other supporting actors include Lauren Lapkus, who plays Handler's "sheltered, shy roommate" Dee Dee, Lenny Clarke, who portrays the comedienne's father.