Neil Patrick Harris stars as Patrick Winslow, a cosmetics executive who stumbles upon the Smurfs after they are magically sucked out of their village into the middle of New York City.
The talented voice cast is led by Jonathan Winters as Papa Smurf.
"I've loved Jonathan Winters forever. I was really excited that he was involved, and what a great voice he has," Harris said. "He's kind of a loose cannon crazy man, and Papa's much wiser and calmer, but boy, when you hear his voice, it's got that depth to it that I wish I had."
"I think it could hypnotize anybody," Jayma Mays said, who plays Grace Winslow, Harris' wife on screen.
Other Smurfs include Anton Yelchin, George Lopez, Katy Perry and Alan Cumming, who says he sees a bit of himself in his alter ego Gutsy Smurf.
"There is something about it that looks like me. And you know, Smurfette does look a little bit like Katy. They've taken elements of all of us and put it in. It's hilarious, I love that," Cumming said.
Another thing Cumming loves is working alone.
"I spend too much of my time surrounded by actors. It's quite nice to act in a scene with nobody," he said. "I don't care if actors take offense, but they're kind of boring sometimes. It's nice to have a break."
"The Smurfs in 3-D" also stars Hank Azaria and Sofia Vergara. The PG-rated film is in theaters on Friday, July 29, 2011.