Labels on the bottles will now list the maximum daily dose as six pills, or a total of 3,000 milligrams, down from eight pills a day or 4,000 milligrams.
The company says it is trying to reduce the risk of accidental acetaminophen overdose.
Acetaminophen is the active ingredient in Tylenol and numerous over-the-counter and prescription drugs
Taking more than the recommended amount can cause liver damage, ranging from abnormalities in liver-function blood tests, to acute liver failure and even death, according to the U.S. Food and Drug Administration.
The Associated Press contributed to this report.