George Lopez joked about the cancellation of "Lopez Tonight" on the TBS talk show and even paid tribute to troubled actor Charlie Sheen.
The cable network had announced on Wednesday that it had decided not to renew the late-night series, whose ratings have declined since its 2009 debut.
"Unemployment is at an all-time high and for Latinos, it just got a little higher," Lopez said during his monologue on "Lopez Tonight" on Wednesday. "We're not saying goodbye - we're saying cable doesn't work."
"Everybody asks ... 'What are you going to do now?'" Lopez added. "Like every TV star before me - I'm gonna find some crack. I'm going to get on the pipe. But I'm taking it good. My goddesses are a wreck. They left me and I'm losing teeth."
Sheen, who has battled alcohol and drug abuse for years, was fired from the hit CBS series "Two and a Half Man" in March after he insulted show co-creator Chuck Lorre in the media and following a rehab stint.
Before he was axed, Sheen, the top-paid TV actor at the time, was suspended from the show. He appeared on various news programs, touting his "winning," party-loving lifestyle and live-in girlfriends, or "goddesses." The actor maintained he was sober, dubbed himself a "rock star from Mars" and demanded a pay raise.
After TBS announced "Lopez Tonight" was canceled, Lopez received Twitter messages of support from fans as well as from several of his fellow comedians and actors, including Ashton Kutcher, who is replacing Sheen on "Two and a Half Men" when it returns for a ninth season in September.
"Thank you El Kutch!" Lopez responded. "How about 3 1/2 men? I'm ready and close by!"
The news of the cancellation of "Lopez Tonight" even spurred a display of unity between comedienne and actress Roseanne Barr and her ex-husband, actor Tom Arnold.
"So sorry to hear of your cancellation--you are great!" Barr Tweeted, to which Arnold responded: "Finally something we agree on! Good luck George."Others who expressed support for Lopez on Twitter include Margaret Cho, Judah Friedlander, "ER" and "Mulan" star Ming-Na, Holly Robinson Peete of "21 Jump Street" and the daytime series "The Talk," Niecy Nash, "Private Practice" actress Kate Walsh and "Rizzoli & Isles" star Angie Harmon, who was scheduled to appear on the show on Monday.
Lopez rose to fame as a comedian and later starred in his own scripted comedy series, "George Lopez," which aired originally between 2002 and 2007.
Lopez also appears in films and has voiced characters in animated movies such as "Beverly Hills Chihuahua," "Rio" and "The Smurfs." He recently filmed the comedy film "The Skank Robbers" with Halle Berry, Jamie Foxx and Martin Lawrence.
The final episode of "Lopez Tonight" airs on Thursday, August 11, at its regular timeslot of midnight and is set to feature Eva Longoria from "Desperate Housewives," which was also canceled recently and is set to air its eighth and final season in September.
Others set to appear on "Lopez Tonight" on Thursday are actor Benjamin Bratt, NBA player Ron Artest of the Los Angeles Lakers, former Guns n' Roses guitarist Slash and comedian Russell Peters.