No officers were injured in the incident.
Ventura Boulevard was closed for several blocks. Several businesses in the area were locked down.
The manager of Delmonico's Lobster House told Eyewitness News that about 20 customers couldn't leave the restaurant because of the active manhunt.
The suspect is believed to be 43-year-old Brent D. Zubek, who is wanted for a double-murder in Chatsworth last weekend.