Mondale, who had been diagnosed with brain cancer years earlier, died early Saturday at her home in Minnesota, said family spokeswoman Lynda Pedersen said.
In a statement emailed to friends, the former vice president said he and his wife "must report that our wonderful daughter, Eleanor Mondale Poling, after her long and gutsy battle against cancer, went up to heaven last night to be with her angel."
Eleanor Mondale had been off the air at WCCO-AM in Minneapolis since March 19, 2009, when she announced that her brain cancer had returned a second time. She had surgery to remove the tumor Aug. 12, 2009, at Mayo Clinic in Rochester, Minn., and a posting on her CaringBridge website declared the surgery a success.
She got her start in broadcasting as an entertainment reporter at WCCO-TV in Minneapolis in 1989.
Mondale also stumped for her father's failed campaign against President Ronald Reagan in 1984.
The Associated Press contributed to this report.
