The trouble started shortly before 10 p.m. Saturday when a California Highway Patrol officer attempted to pull over a Jaguar for speeding.
The Jaguar exited the freeway at Main Street, but then got back on going the wrong direction. Seconds later, the Jaguar crashed into a pickup truck.
The collision occurred on the westbound side of the 60 Freeway near Main Street.
Both people in the Jaguar were killed and two people in the truck were taken to the hospital. Their conditions were unknown.