Officials said the incident happened around 10:30 p.m. in Redlands on the westbound lanes of the freeway, north of San Bernardino Avenue.
Authorities said a white pick-up truck was pulled over on the side with its emergency lights on. According to a witness, a vehicle pulled up and someone shot the driver of the truck.
The 42-year-old victim from Anaheim was taken to the hospital to undergo surgery and is in stable condition.
Police are trying to determine if there's any connection between this crime and a series of armed freeway robberies in the area last month.
Over a two-day period in September there were nine incidents, seven of them on Inland Empire freeways, where suspects robbed drivers after their cars broke down. No arrests have been made in those cases.
"The ones that were investigated by the CHP, some of those occurred on the I-210," said Carl Baker of the Redlands Police Department. "There is the similarity of disabled motorists. Beyond that, whether this is related or not, it's too early to say."
Two suspects were caught on camera after allegedly targeting a security guard in Mentone. They were seen driving a white utility truck, but witnesses to some of the attacks reported seeing a red sedan.
The suspects in Monday night's shooting escaped in a maroon or dark red four-door 2010 Ford Focus or Chevrolet Cruze with a tinted rear window.
There was also an attack on the I-10 in Ontario on Monday night.
Anyone with information is asked to contact the Redlands Police Department at (909) 798-7681.