Luis Manuel Tapia, 35, Diana Sophia Zamora, 23, and Edgar Rafael Aguilar, 29, were arrested on federal drug distribution and firearms trafficking charges.
The bust was part of the second phase of "Operation Supernova," which is an investigation into the Colonia Chiques gang.
During the undercover operation in Camarillo, a gang member agreed to sell undercover agents 10 pounds of methamphetamine and four kilograms of cocaine for $200,000.
Authorities also seized an AK-47 and a sawed-off shotgun during the investigation.
In the first phase of the operation, federal prosecutors convicted 11 people who received sentences of up to 25 years in prison.
Police said Colonia Chiques, which was formed in the 1970s, has more than 1,000 documented members and has strong ties to the Mexican Mafia prison gang.