Daniel Craig will make his third outing as the suave British superspy, and Spanish star Javier Bardem will co-star as Bond's nemesis.
Sam Mendes is directing the film, which will be shot in London, Scotland, Turkey and China.
Craig told reporters that the movie would be "Bond with a capital B" and said he was "tremendously excited" to be stepping back into the role for the first time since 2008's "Quantum of Solace."
Work on the film was postponed, and Bond's future looked uncertain, when studio MGM filed for bankruptcy in 2010. But MGM's new management and EON Productions announced earlier this year that the spy would live to fight another day.
"Skyfall" is due to be released on Oct 26, 2012 in Britain and Nov. 9 in the United States, 50 years since the release of the first 007 film, "Dr. No."
The Associated Press contributed to this report.