The incident happened just before 9 p.m. Sunday in the 500 block of 84th Street.
Police said the man was getting out of his vehicle when the shooting happened. He was rushed to a hospital but died before crews could get him there.
The man's son was in the passenger seat when the shots rang out, but he was not hurt.
Police don't have a motive or suspects for the shooting.
Anyone with information was asked to call the Los Angeles Police Department at (877) LAPD-24-7.