The company is concerned that the bottles could contain stray pills from other medicines, or chipped or broken tablets.
The company said it wanted to make sure that customers didn't take any pills that they might be allergic to or that might become dangerous when mixed with their other medications though it also said that there have been no such reports from consumers.
The recall includes Excedrin and NoDoz with expiration dates of December 20, 2014 or earlier.
Packages of Bufferin and Gas-X with expiration dates of December 20, 2013 or earlier are also affected.
The news follows Novartis' recent decision to temporarily suspend production at its Lincoln, Neb., plant for "maintenance and other improvement activities."
Customers can call the company for more information at 1-888-477-2403 Monday to Friday, 6 a.m. to 5 p.m. PT.
The Associated Press contributed to this report.