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OTRC: Chelsea Handler's NBC show 'Are You There, Chelsea?' debuts on Wednesday (Video, Poll)

Laura Prepon (left) and Chelsea Handler appear on a 2012 episode of 'Are You There, Chelsea.' (NBC)

Chelsea Handler's new NBC sitcom "Are You There, Chelsea," debuts on Wednesday and marks her big network television debut following the success of her talk show "Chelsea Lately," which airs on the E! cable channel and has made her a national star.

The new show is loosely based on the raunchy comedienne's best-selling book, "Are You There Vodka? It's Me, Chelsea." Laura Prepon, 31, plays the comedienne, who works as a cocktail waitress at a New Jersey sports bar.

Handler, 36, stars as her real-life older sister, Sloane. She wears a brunette wig to play the character, who is initially pregnant. The series also features "Glee" actress Dot-Marie Jones as a guest star.

"I give birth in the first episode; something ill never let happen in real life," Handler, who does not actually have any children and has often joked about her love life, said on her Twitter page on Wednesday.

She told reporters earlier last week that Prepon is the real "star of the show."

"It's a dream come true to have someone else portray me because I've been living this life for a long time, and I'm over myself," Handler said, according to the Associated Press. "It's a pleasure to play my sister because everything I've been accusing her of my whole life, I can now re-enact before her eyes."

"Are You There, Chelsea" airs at 8:30 p.m. ET, after "Whitney." The half-hour comedy, which stars recurring "Chelsea Lately" comedienne Whitney Cummings, debuted last fall.

Handler performed stand-up comedy for years before scoring small acting roles, mainly on television, during the past few years. She made a guest appearance on "Whitney" last year.

"Chelsea Lately" debuted in 2007 and was recently renewed for at least two more years.

"I do behave badly and I get paid handsomely for it so I'm happy, happy to do it," Handler said on the CNN show "Piers Morgan Tonight" in November. "It's a really good time to be me."

Check out sneak peek videos for "Are You There, Chelsea?"

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