The singer-actress won five awards, including favorite female artist, tour headliner, song of the year for "E.T." with Kanye West, music video for "Last Friday Night" and TV guest star for "How I Met Your Mother."
This would have been the pop star's first public appearance since British actor-comedian Russell Brand filed for divorce from Perry last month after 14 months of marriage.
"Harry Potter and the Deathly Hallows: Part 2," followed behind Perry with four wins for favorite movie, action movie, book adaptation and ensemble movie cast.
Teen star Demi Lovato was voted favorite pop artist and "Glee" star Lea Michele was voted favorite TV comedy actress.
Other big winners included Johnny Depp as favorite movie actor, Emma Stone as favorite movie actress, Lady Gaga's "Born This Way" as favorite album and Maroon 5 as favorite band.
The Associated Press contributed to this report.