Chris Paul was spectacular, scoring 33 points on an array of drives to the hoop and jumpers. He also managed to dish out six assists on the night as the Lakers had no answers for the Clippers' point guard.
Kobe Bryant notched his fourth straight 40-point outing, scoring 42 points to keep the Lakers in it. But Paul was too much for the Lakers- finding Blake Griffin for the dunk to help seal the game.
Griffin had 22 points and 14 rebounds, Chauncey Billups added 19 points, former Laker Caron Butler had 13 points and DeAndre Jordan had 10 rebounds in the Clippers' second win in four days over one of the NBA's elite teams.
There were six technical fouls called between the two teams during Saturday night's game.
The Clippers beat Miami 95-89 in overtime on Wednesday and have won five of their last six.
The Lakers had their five-game winning streak snapped by their Staples Center co-tenants, who beat them twice in the preseason.
The Associated Press contributed to this story.