Evin Ortiz, 22, of Valley Glen and Rene Ramirez, 29, of Panorama City are scheduled to make court appearances Wednesday. A third suspect remains at large and unidentified.
Last week, 24-year-old Danilo Morales chased after three men who police say robbed his 68-year-old grandfather on Coldwater Canyon Avenue.
One of the suspects fatally shot Morales.
Ortiz and Ramirez were charged with one count each of special-circumstance murder, attempted murder, assault with a firearm, and second-degree robbery.
The special circumstance of murder for robbery makes this a potential death penalty case. Prosecutors will decide later whether to seek the death penalty.
Anyone with information related to the case should contact the Los Angeles Police Department at (877) LAPD-24-7.