Tatum mixes it up with mixed martial arts champ and acting newcomer Gina Carano.
He's fought plenty on screen and she's fought plenty in the ring. But this marks her first screen kiss.
"I think we've all kissed. I think everybody's had somebody in their life by now. She's not a wallflower. She didn't grow up in a convent and I didn't either," Tatum said."I definitely know that she was like, 'What are we supposed to do? Like, how does this work?' I'm like, 'I don't know. Let's just do it.' It was fun."
Tatum is about to spend a lot of time at the box office. After "Haywire," he stars in the romantic drama, "The Vow," opposite Rachel McAdams. It opens on Valentine's Day.
In March, it's "21 Jump Street" with Jonah Hill.
Come summer, he's back in action in the "G.I. Joe" sequel.
Tatum looks at every role as another building block in his career.
"I just want to be more and more involved in the building of it," he said. "My acting coach told me that it's going to take 10 years to even be good at this. I think I'm on year eight, so I'm getting close to being good."
Tatum's other upcoming film is the male stripper comedy "Magic Mike," one of two movies he's produced.
He's not stopping there.
"I want to direct some day," Tatum said. "I want to start failing early at directing and just get it going. I love storytelling and I think, ultimately, I'll never stop as long as you guys keep letting me."
"Haywire" is rated R and opens Friday.