Detectives on Monday raided Herbal Medicine Care on the 10100 block of Topanga Canyon Boulevard in Northridge.
Three suspects were arrested and more than 50 pounds of pot and thousands of dollars in cash were seized.
Though they're happy with their success, authorities said there's more work to be done.
"We're not done yet. There are approximately 200 other locations within the San Fernando Valley that we're also going to be targeting and specifically addressing to ensure that we don't have storefront locations that are operating illegally with their sales of marijuana," said Deputy Chief Jorge Villegas of the Los Angeles Police Department.
Police said many people have set up similar storefronts to illegally sell pot for profit and not medical purposes.