The incident was reported shortly before 1 a.m. Monday near West 87th Place and South Broadway.
The victim was shot in the head, officials said. He was pronounced dead at the hospital.
The shooting happened near a motorcycle club, but police said it's unclear if the club is connected to the crime.
Authorities said people at the scene were not immediately cooperating with the investigation.
Anyone with information was asked to call the Los Angeles Police Department's Southeast Station at (213) 972-7828.