The trip is expected to take about 10 days, as the 21 1/2-foot-tall boulder will travel through nearly two dozen cities. It will only be moved during late night and early morning hours.
Officials said it can't take a more direct route because freeway bridges would not be able to withstand the strain. Instead, the route will detour on surface streets. Traffic signals will have to be disassembled and power lines will have to be cut. Everything will have to be reassembled before morning commuters hit the streets.
The 105-mile journey will end at LACMA's backyard where it will be the centerpiece of artist Michael Heizer's "Levitated Mass" exhibit. The rock will appear to float above the heads of visitors as they walk underneath it.
The granite is expected to arrive at LACMA March 10. Museum officials hope to have the exhibit open by late spring or early summer.
City News Service contributed to this story.