Several people did win smaller prizes, though.
Here are the winning numbers: 6, 17, 19, 20, 21 and the Mega Ball number 20.
There were 39 tickets sold with the first five numbers, including seven in California. Those tickets are worth more than $259,000 each. Of the seven, two were sold in Los Angeles County with one in Commerce and the other in Montebello.
The next drawing is Tuesday, March 27.
The odds of matching all five numbers and the Mega number is 1 in 175,711,536, according to the Mega Millions website. The overall chance of winning a prize is 1 in 40.
The Mega Millions game is played in 41 states, the District of Columbia and the U.S. Virgin Islands.
City News Service contributed to this report.