The stolen instruments include Petty's blond 1967 12-string Rickenbacker and his Gibson SGTVJunior, Mike Campbell's blue Dusenberg Mike Campbell model, Ron Blair's Fender Broadcaster and Scott Thurston's 1967 Epiphone Sheridan.
On its website, the band posted detailed descriptions of the instruments, along with a "no questions asked" reward for $7,500. Pictures and serial numbers of the guitar were posted as well.
Culver City police said the theft at Culver Studios at 9336 W. Washington Blvd. was reported Thursday.
The band asked anyone with information about the guitar heist to contact StolenGuitars@TomPetty.com or call Culver City police at (310) 253-6305.
City News Service contributed to this report.