Bradbury's daughter said her father died Tuesday night, but she did not provide additional details.
Although he suffered a stroke, Bradbury was still writing into his 90s with new novels, plays, screenplays and poetry.
Bradbury is known for scripting John Huston's 1956 film version of "Moby Dick." He also wrote for "The Twilight Zone" and other TV programs.
"His gift for storytelling reshaped our culture and expanded our world. But Ray also understood that our imaginations could be used as a tool for better understanding, a vehicle for change, and an expression of our most cherished values," President Barack Obama said in a statement. "There is no doubt that Ray will continue to inspire many more generations with his writing, and our thoughts and prayers are with his family and friends."
Just a year and a half ago, Bradbury was honored at L.A. City Hall, where he talked about how growing up in L.A. shaped his life.
"I never went to college, I had no money to do that, so I went to all the libraries in L.A., and I read all the books," he said.
Despite his lack of a college degree, Bradbury was highly respected in the literary world.
Longtime fans stopped at Bradbury's star on the Hollywood Walk of Fame on Wednesday to reminisce about the imaginative tales he created.
"Ray Bradbury is really kind of, to me, the father of reading, that's what he taught us to do. He taught us to visit bookshops and libraries and read and read and read," said fan Terry Ellett.
Bradbury is survived by his four daughters. His wife of 56 years died in 2003.
The Associated Press contributed to this report.