Bryson informed President Barack Obama on Monday that he was taking a medical leave "so that I can focus all of my attention on resolving the health issues that arose over the weekend," according to a statement released by the department. Deputy Secretary Rebecca Blank will serve as acting commerce secretary in Bryson's absence. It was unknown how long his medical leave of absence would last.
Authorities found the 68-year-old unconscious behind the wheel of his Lexus on Saturday after they say he hit one car in San Gabriel and another minutes later in Rosemead. White House officials say Bryson suffered a seizure.
Sheriff's deputies are waiting for the results of Bryson's blood test, but say there's no evidence he was driving under the influence. Bryson was cited for felony hit and run.
The Associated Press contributed to this report.