The epicenter was 36 miles southeast of Calexico and 106 miles east-southeast of San Diego. A magnitude-3.0 temblor followed a few hours later near the Mexican city of Guadalupe Victoria in Baja California.
There were no reports of any major damage.
Calexico wasn't so lucky back in April 2010 when a 7.2-magnitude temblor shook nearby Mexicali. The quake killed two people and damaged dozens of buildings.
City News Service contributed to this report.