Rhys Ifans described his character's fall from grace in "The Amazing Spider-Man" as "tragic" at the film's recent premiere in Los Angeles.
"He's under tremendous pressure for the organization he's working for, the cooperation being Oscorp," Ifans explained to reporters on June 28. "They want to advance his product, this serum that will enable the rebuild of limbs and they want to test it on members of the public and Dr. Connors takes the moral high ground and becomes his own lab rat."
"It becomes tragic," he added. "In regaining his arm, he has to lose his mind."
In the "Spider-Man" reboot, Peter Parker (Andrew Garfield) goes in search of clues that might explain what happened to his parents, who disappeared when he was young. His search brings him to Dr. Curt Connors (Ifans), his father's former partner.
Gwen Stacy, Parker's first love, is played by Emma Stone.
Ifans also talked about what it was like seeing a CGI version of himself as The Lizard in 3D.
"It was like climbing into a mosquito and then flying around your own head," he said.
Rhys is most likely known for playing Spike, the best friend to Hugh Grant's character in the 1999 hit film "Notting Hill." He also appeared as Xenophilius Lovegood in "Harry Potter and the Deathly Hallows: Part 1."
So what can audiences expect from his performance? Ifans said, "Probably move them and make them think, possibly."
"The Amazing Spider-Man" is slated for release on July 3, 2012. Watch a trailer below.
Reporting by George Pennacchio of KABC Television, parent company of OnTheRedCarpet.com that also produces the entertainment show "On The Red Carpet"(check for local TV listings).