The shooting happened around 2:45 p.m. on the 1500 block of West 9th Street. Several children were inside the home at the time. None of them were hurt.
The two victims died from their wounds after being taken to a hospital. One victim was identified as 33-year-old Floyd Walker Jr. of San Bernardino. The second victim's identity was not released, pending family notification.
Officials did not have a suspect description. The shooting remains under investigation. Anyone with information was asked to call the San Bernardino Police Department at (909) 384-5738.