The pursuit began around 2:30 a.m. on Orangethorpe and Raymond avenues in Fullerton when the suspect refused to stop for officers after running a red light.
Police chased the suspect on and off the freeway before cornering him on the cul-de-sac at Palo Verde Avenue and Artesia Boulevard in Bellflower. Officers opened fire on the suspect after they say the driver tried to run them over. The suspect, said to be a male in his mid to late 20s, was pronounced dead at the scene.
"Multiple officers exited their vehicles at which time the suspect tried to run over several officers and an officer-involved shooting occurred," said L.A. County Sheriff's Lt. Dave Coleman.
Two Fullerton police officers unloaded more than 10 rounds on the suspect, according to sheriff's officials.
No officers were injured, but the Los Angeles County Sheriff's Department says the suspect collided with at least three police cruisers during the pursuit.
The area remained closed for hours for an investigation, which was taken over by the Los Angeles County Sheriff's Department.
The incident remained under investigation Wednesday night.