The pop star arrived at the Solomon R. Guggenheim Museum Thursday night on top of a convertible. She then jumped inside a giant-sized perfume bottle, which was a replica of her "Fame" fragrance.
While she was inside the glass bottle, the singer stripped down to her lingerie, played on an iPad and got a tattoo on the back of her neck.
Celebrity attendees included Yoko Ono, Marc Jacobs, Paris Hilton and Lindsay Lohan.
At the black tie masquerade event, the star also debuted a short film called "Lady Gaga Film," which was a collaborative effort with director Steven Klein.
The Grammy-winning singer released her multiplatinum debut, "The Fame," in 2008. That was followed by the platinum-selling albums "The Fame Monster" and last year's "Born This Way."
The Associated Press contributed to this report.