The largest demonstration was in Beirut, Lebanon, where the crowd demanded that Americans criminalize speaking negatively about monotheistic religions or their prophets. Thousands showed up for the protest, answering a call from Hezbollah, a group America says is a terrorist organization.
Hezbollah leader Hassan Nasrallah gave a rare speech. He wants the U.S. to be held accountable for the film because it was made in America.
"The world until now cannot comprehend the degree of insult this disgusting film caused to the Prophet Mohammed," he said.
Hundreds clashed with police outside the U.S. embassy in Jakarta, Indonesia, hurling rocks and firebombs. Police used water cannons and tear gas to break up the crowd.
In Afghanistan, demonstrators shouted "Death to America" outside a U.S. military base in Kabul. At least 15 police officers were injured, and two police cars were burned. In Pakistan, police lobbed tear gas and fired guns into the air to stop protesters from reaching the U.S. embassy in Karachi. An official said one protester was killed in an exchange of gunfire with police. Protesters eventually surrendered, according to police.
"We have to be concerned because this is one way they've been able to penetrate our defenses. We have to find a way to stop it," said New York Rep. Peter King.
Some are wondering whether it's time to take Prince Harry out of Afghanistan's Camp Bastion. Fifteen Taliban fighters disguised themselves in American military uniforms and blasted a hole in an outer wall this weekend.
Their target was an air field where Harry's helicopter was parked. The prince was at least a half-mile away when the attack occurred.
Protests seemed to cool down in places like Cairo, Egypt and Lebanon, but leaders at the massive gathering in Beirut are calling for four straight days of similar protests.
The Associated Press contributed to this report.