The first couple will sit down with "The View" hosts Barbara Walters, Whoopi Goldberg, Joy Behar, Elisabeth Hasselbeck and Sherri Shepherd as part of the show's continuing "Red, White & View" campaign, which has included political guests and discussions on current election news.
The interview, scheduled to be taped Monday and air Tuesday, will touch on such topics as their relationship, family life inside the White House and the election.
"We are honored to host President Obama and first lady Michelle Obama on "The View," said Walters in a statement. "Although each of them has appeared several times on the program, this first joint appearance marks a significant milestone."
The Obamas have each appeared individually on "The View" -- this will mark the president's fifth appearance and the first lady's fourth. Mr. Obama's appearance in July 2010, marking the first time a sitting U.S. president visited a daytime talk show, was the show's most-watched episode ever, totaling 6.59 million viewers.
Republican challenger Mitt Romney has not yet appeared on the show. He told donors privately in remarks made public this week that going on "The View" is risky because only one host is conservative, and the other four are "sharp-tongued."
Hasselbeck, the conservative host Romney mentioned, said she has asked Romney to come on the show. According to his campaign, an October appearance is likely to be scheduled.