In all, 530 unionized jobs are being cut. That's out of Kaiser's nearly 66,000 staff members in offices and hospitals from Kern County south to San Diego County. Doctors were not affected.
Laid-off employees will continue to be paid and receive benefits for one year, under certain contracts.
Kaiser said it hopes to rehire some of those employees in the future after the federal Affordable Care Act is implemented.
A Kaiser spokesperson said exact layoff locations were not available because some of the affected employees may be offered other vacant positions as it makes staffing adjustments next week.
The Associated Press and City News Service contributed to this report.