Cirque officials announced the last performance of "Iris" will be Jan. 19, 2013.
"Iris" opened in September 2011, thanks to a $30 million loan from the city's Community Development Department.
It was all part of a makeover of the partly city-developed venue, then known as the Kodak Theatre.
Cirque officials told the Los Angeles Times they are exploring the possibility of taking the show to other cities. The company said it would "redeploy as many of our artists and employees as possible to other Cirque du Soleil projects."
"Iris" employed almost 70 performers along with 100 to 120 other individuals, including technicians and support staff.
City News Service contributed to this report.