The double shooting occurred near the 4500 block of West Slauson Avenue.
The injured victims made their way to a 711 at Slauson Avenue and Angeles Vista Boulevard where police were called around 1:30 a.m.
The woman was taken to the hospital but was shortly pronounced dead.
The man was being treated for gunshot wounds.
The victim's names have not been released pending notification of kin.
Police have not made an arrest nor have released any information regarding a possible motive.