The shooting occurred around 2:05 a.m. Sunday outside Empire on the 1700 block of North Cahuenga Boulevard. According to LAPD, the incident began with a fight and soon escalated into gun violence.
"A fight inside the nightclub spilled outside", LAPD Sgt. Mark Ro said.
The motive for the shooting remains under investigation.
Police say the suspects took off after opening fire. The man who authorities believe opened fire was described as a black male standing around 5 feet 8 inches tall.
The second victim was described as a male between 20 to 25 years old. An unidentified woman who was crossing the street near the club also suffered a graze wound but did not require hospital treatment.