Authorities say the pursuit started after the driver, a parolee, made an illegal U-turn at about 8:30 p.m. at Speedway and 20th Street.
The chase ended on Lincoln Boulevard and Vernon Avenue after the suspect plowed into Wurstkuche.
The suspect, the cyclist, and three other people were hospitalized following the crash. None of the injuries were believed to be life threatening.
The restaurant was shut down after sustaining structural damage when the truck crashed through the gas and panel wall.
The suspect is now facing suspicion of felony hit and run and felony evading.
Lincoln Boulevard near Vernon Avenue was shut down temporarily as authorities investigated the incident.