Financial details of the agreement between StubHub and the stadium's management company, AEG, weren't available.
The deal includes advertising signs throughout the center and on digital billboards alongside nearby freeways. This is the first naming rights venture for the San Francisco-based online ticket retailer.
The 125-acre facility has been known as the Home Depot Center since it opened 10 years ago. Home Depot paid $70 million for a 10-year deal. The company declined to renew.
StubHub Center will remain an official U.S. Olympic and Paralympic training site, and a training center for the U.S. Soccer Federation, the U.S. Tennis Association and USA Cycling.
The Associated Press contributed to this report.