The shooting occurred near Sunset Boulevard and Echo Park Avenue around 12:15 a.m.
According to authorities, officers responded to the location following reports of an armed man shooting a gun. Arriving officers spotted a man matching the suspect's description and chased him on foot.
That's when police say the suspect turned and pointed an unknown object at the pursuing officers and an officer-involved shooting ensued.
The man, identified as a man between 35 to 40 years old, was hospitalized in critical but stable condition following the shooting.
Police say he was unarmed at the time of his arrest.
The incident remains under investigation.