The road is used by many commuters traveling to and from the Valley and the West Side. Crews will be replacing a 100-year-old water main pipeline. The project aims to avoid a rupture in the future.
"We've already seen it break twice. We know it's going to break again and it breaks catastrophically and does millions of dollars of damage that the ratepayers of Los Angeles have to pay for," said Jeff Bray with the Department of Water and Power.
The road is expected to be closed from 8:30 a.m. to 6 p.m. every day until the DWP project is finished. Crews are hoping they can finish the construction early.
"We're making three connections of the 60-inch pipe, so we have three work areas," said Bray. "There's a slight possibility we may get done a little bit early, but we're anticipating there may be some rain or some delays that we can't anticipate with this type of construction."
Alternative routes include the Cahuenga Pass, Laurel Canyon Boulevard and Sepulveda Boulevard.
Drivers will face another big traffic problem this weekend with the closure of the northbound 405 Freeway from Getty Center Drive to the 101 Freeway. Ramps will be shut down as early as 7 p.m. Saturday leading up to a full closure from 1 a.m. to 6 a.m. The work allows crews to install structures on the Mulholland Bridge.