The website banned an unrated version of "Blurred Lines" without releasing an official reason.
The R&B crooner tweeted about the ban on his Twitter page.
"YouTube took down the Unrated version of #BLURREDLINES because it was too hot! You can still view it here on @VEVO," Thicke tweeted.
The steamy music video, which was released last week, features nude models prowling around Thicke and rappers T.I. and Pharrell.
Despite its disaproval from YouTube, the video has already received more than a million views.
In a recent interview, Thicke said he got approval from his wife, actress Paula Patton, to shoot with nude models.
The Associated Press contributed to this report.