The incident happened near Everett and East 58th Street, where Los Angeles County sheriff's deputies confronted a man and a woman at about 11:40 p.m. Wednesday.
Investigators say the man was acting suspicious and reached for his waistband. That's when deputies opened fire. The man, described as a 31-year-old, is expected to survive.
Officers found a large spray-paint can in his pocket, but no weapon.
Charges are pending against both suspects. No deputies were injured.
If you have any information about this incident, you're urged to contact the Los Angeles County Sheriff's Department's Homicide Bureau at (323) 890-5500.