The fire was reported coming from a fourth floor office on the 3600 block of Watt Way around 9:42 a.m.
Firefighters say there was heavy smoke but the fire was quickly controlled by a sprinkler system.
The fire was fully contained in less than 10 minutes.
Officials say USC staff managed to coordinate an orderly evacuation.
No injuries were reported. Los Angeles Fire Department spokesman Brian Humphrey says the fire may have been caused by computer equipment.
The investigation is ongoing.