The incident happened on the 44800 block of Hanstead Avenue around 4:30 a.m.
Homicide detectives say the unidentified victims were part of a group of men gathered in front of a house down the street when a verbal argument among the group turned physical.
An unknown suspect shot the two men multiple times in the upper torso. The victims did not survive their injuries.
Authorities say several cars were seen leaving the area.
No arrest has been made.
Anyone with information was asked to call the Los Angeles County Sheriff's Department's Homicide Bureau at (323) 890-5500.