Kelly's car stalled and blocked the right lane of the 5 Freeway near Olive Avenue in Burbank on Saturday. Police who responded questioned if she had been drinking.
After an investigation, Kelly was arrested on suspicion of drunken driving. She was released Monday morning on $5,000 bail.
This was not her first run-in with the law. Kelly was arrested twice in 2012 for alleged spousal assault.
Kelly played Laurie Forman, sister of Topher Grace's lead character Eric, on the FOX series, which ended in 2006.
The Associated Press contributed to this report.