The accident was reported just before 11:30 a.m. Saturday on the northbound 14 Freeway at Agua Dulce Canyon Road.
CHP officers say a semi-truck collided with a sedan parked on the side of the freeway. The impact caused the car to strike two people standing on the side of the road.
A rescue helicopter that was flying over the area landed and then transported the two victims to a local hospital. The CHP says one victim was pronounced dead at the hospital. The condition of the second victim is not known.
Officers say the truck kept going after the crash. It's not clear if the driver knew they had hit another vehicle. Someone followed the semi-truck, which was eventually stopped by the CHP.
The crash closed all but one of the northbound lanes for more than an hour, which caused a major traffic backup. The CHP says the traffic jam and scorching heat caused between 30 and 40 vehicles to overheat.