It started with a shooting around 10:30 p.m. Sunday at a home in the 14000 block of Vose Street in Van Nuys.
Police say a man walked into the home and shot the woman. She was transported to Cedars Sinai Medical Center, where she was listed in critical but stable condition.
Police arrived on scene, and that's when the man led officers on a two-hour pursuit, which went through the cities of Camarillo, Oxnard and Ventura before returning to Van Nuys.
Officers used a pit maneuver to stop the driver at Sherman Way and Haskell Boulevard.
The man shot himself in the head and died at the scene, said authorities.